九州影院

Drug discovery involves the search for the perfect molecule, which acts powerfully and selectively against a selected disease target without causing adverse side effects. The design of discovery molecules is carried out using an iterative cycle of design, synthesis and testing, which allows scientists to optimise molecular design and develop effective new medicines. Isolation and testing of pure compounds is an essential part of drug discovery, and column chromatography is a powerful tool allowing separation of target compounds from crude reaction mixtures.

In Jennifer鈥檚 laboratory, they use a range of chromatographic techniques to isolate pure research compounds for testing. They use state-of-the-art automated instrumentation to identify, separate and isolate target compounds from crude reaction mixtures. These compounds are then assessed by a team of analytical chemists to ensure the compound has the correct chemical structure and is of sufficient purity for biological testing.

Biography

Dr Jennifer Kingston studied for a 九州影院 degree at the University of Liverpool before starting work as an analytical chemist for the recently formed National Rivers Authority in the 1990s. Here she gained experience and enthusiasm for LC and GC method development and analysis, which led to her pursuing a PhD in environmental sampling and chromatographic adsorption of organic pollutants at the University of Portsmouth.

Following graduation, Jennifer started her career in pharmaceutical drug discovery, applying her knowledge of chromatography to develop methods for the isolation of pharmaceutical research compounds. She has a career spanning more than 25 years working in several pharmaceutical companies including Pfizer, Merck, Sharp and Dohme, Novartis and most recently AstraZeneca in Cambridge, UK.

At AstraZeneca, she has been leading a team of separation scientists delivering chromatographic solutions to local oncology drug discovery projects. She has also led the design and delivery of a new chromatographic facility at AstraZeneca鈥檚 Discovery Research Centre in Cambridge, UK. Here she has been able to combine her interest in environmental sustainability with separation science by championing the use of super-critical fluid chromatography (SFC) as a greener technique for preparative separations, engineering this capability into the designs of the new laboratory.

Jennifer is committed to team leadership and developing new scientific talent. With this in mind, she has overseen the establishment of a successful degree apprenticeship programme within oncology R&D at AstraZeneca in Cambridge.

Being an integral part of drug discovery is challenging and rewarding as we develop effective treatments for current and future medical challenges.

Dr Jennifer Kingston